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　　1992年山東大學(xué)微生物系微生物學(xué)專(zhuān)業(yè)畢業(yè)，獲理學(xué)學(xué)士學(xué)位;2001年北京大學(xué)生命科學(xué)院分子細(xì)胞生物學(xué)專(zhuān)業(yè)畢業(yè)，獲理學(xué)博士學(xué)位;2001-2004年在美國(guó)哈佛大學(xué)醫(yī)學(xué)院從事博士后研究工作;2004-2008年在美國(guó)德州大學(xué)西南醫(yī)學(xué)中心從事博士后研究工作。2008年6月起任中科院上海生科院生物化學(xué)與細(xì)胞生物學(xué)研究所(現(xiàn)中國(guó)科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心)研究員，研究組長(zhǎng)。

　　細(xì)胞是生命活動(dòng)的基本單元，細(xì)胞的生長(zhǎng)、增殖、分化、機(jī)體發(fā)育以及對(duì)環(huán)境刺激的應(yīng)答，代謝水平的維持等基本生命活動(dòng)均受到多種細(xì)胞內(nèi)外信號(hào)的動(dòng)態(tài)調(diào)控。細(xì)胞感受細(xì)胞內(nèi)外多種信號(hào)，協(xié)調(diào)機(jī)體內(nèi)周?chē)募?xì)胞做出特定的反應(yīng)，是機(jī)體生命活動(dòng)的基礎(chǔ)。而相關(guān)調(diào)控的異常也將導(dǎo)致包括發(fā)育疾病、癌癥、代謝類(lèi)疾病在內(nèi)的多種嚴(yán)重疾病的發(fā)生。深入理解細(xì)胞內(nèi)在調(diào)控規(guī)律是理解細(xì)胞的正常功能以及人工干預(yù)和糾正細(xì)胞病理狀態(tài)下異常功能的基礎(chǔ)。

　　聚焦上述科學(xué)問(wèn)題，實(shí)驗(yàn)室綜合利用細(xì)胞生物學(xué)、發(fā)育生物學(xué)、生物化學(xué)、分子生物學(xué)、遺傳學(xué)等技術(shù)手段和方法，在分子、細(xì)胞、組織、器官及動(dòng)物整體等多個(gè)層次研究相關(guān)信號(hào)通路的分子調(diào)控機(jī)制以及其在機(jī)體組織器官發(fā)育、代謝、干細(xì)胞干性維持、腫瘤發(fā)生發(fā)展及腫瘤免疫中的生物學(xué)功能。

1. Chaoxiong Wang,?Peixuan Zheng,?Anhui Wang,?Xinrui Fan,?Tianxiang Li,?Jingjing Hong,?Runze Wang,?Chunyan Zhang,?Chaogui Luo,?Weiwei Yang,?Dong Gao,?Adili Salai,?Min Luo,?Zhigang Lu,?Dianfan Li*,?Moubin Lin*,?Jiayin Peng*,?Guohui Li*,?Shuo Han*,?Yun Zhao*. CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+?T cells. Nature Cancer. 2026 May 15. ?doi: 10.1038/s43018-026-01169-4.?Online ahead of print. (* co-corresponding author)
2. Yajuan Zhang,?Qizhen Fei,?Yan Li,?Siyao Wang,?Tong Rong,?Xueyuan Wu,?Hong Gao,?Chen Chen,?Dong Gao,?Yun Zhao,?Guohui Li,?Huiying Chu,?Wenfeng Li,?Weiwei Yang. An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression. ?Nature Communications. 2026 Jan 21.?doi: 10.1038/s41467-026-68699-4.
3. Man Jiang, Yu Li, Yiao Jiang, Runze Wang, Jiayin Peng, Yuang Wang, Zhen Qu, Yi Chang*, Zhao Zhang*, Yun Zhao*. Hilnc-mediated UCP1 translation repression contributes to thermogenesis and energy expenditure. Theranostics. 2026; 16(7): 3263-3285. doi: 10.7150/thno.122688. (* co-corresponding author)
4. Bing Liu,?Min Liu,?Yajuan Zhang,?Yifei Zhu,?Dingpei Zhou,?Hong Gao,?Fan Yang,?Dong Gao,?Yun Zhao,?BangBao Tao,?Feng Yao,?Weiwei Yang.?Compression-induced NF-κB activation sustains tumor cell survival in confinement by detoxifying aldehydes and promotes metastasis. ?Nature Communications. 2025 Dec 14. doi: 10.1038/s41467-025-67452-7.?
5. Wei Jiang,?Ailing Yang,?Jingchuan Ma,?Dawei Lv,?Mingxian Liu,?Chao Wang,?Shuo Chen,?Huiling Fang,?Yankai Chu,?Zhengjin He,?Wenrui Li,?Yucheng Liu,?Yun Zhao,?Zhaocai Zhou,?Gang Long,?Hai Jiang. Genetic determinants of efficacy of antiviral drugs revealed by genome-wide CRISPR screens. Antiviral Research. 2025; 244:106309. doi: 10.1016/j.antiviral.2025.106309.?
6. Zhengjin He,?Shishuang Chen,?Jinlong Suo,?Kai Xia,?Mingxian Liu,?Jingchuan Ma,?Yankai Chu,?Chao Wang,?Yueru Xie,?Wei Jiang,?Hui Du,?Shiyang Chen,?Zhilei Zhou,?Man Li,?Qing Wei,?Yun Zhao,?Jianfeng Chen,?Lin Li,?Yi Zeng,?Weiguo Zou,?Moubin Lin,?Hai Jiang. STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency. Cell Chemical Biology. 2025; 32(11):1321-1335.e6. doi: 10.1016/j.chembiol.2025.10.001.
7. Lili Han, Fengmin Zhang, Jujin Zhang, Xiaonan Li, Kunpeng Wang, Biao Liu, Jiawen Song, Xinyan Liu, Yun Qian, Kai Li, Yingnan Lei, Claudia Spits, Yi Chang, Chengle Zhuang, Zhen Yu, Yun Zhao*, Jiayin Peng*. Gli1 regulates fibro/adipogenic progenitor function through modulation of Ido1 in muscle regeneration. International Journal of Biological Sciences. 2025; 21(14): 6197-6214. doi: 10.7150/ijbs.116134. (* co-corresponding author)
8. Yankai Chu,?Shishuang Chen,?Mingyang Yang,?Yin Chen,?Huiling Fang,?Pinyu Huang,?Yueru Xie,?Chi Sun,?Yun Chen,?Baoding Zhang,?Li Li,?Hongchen Mu,?Ding Song,?Wentao Cheng,?Chao Wang,?Wei Jiang,?Xiaolan Xu,?Zhengjin He,?Shuo Chen,?Mingxian Liu,?Jingchuan Ma,?Man Yang,?Jiaqi Cao,?Jing Gao,?Jiali Shen,?Lulu Zhang,?Yu Bai,?Zheyi Liu,?Jingyao Chen,?Siqi Dai,?Yi Arial Zeng,?Yun Zhao,?Hu Zhou,?Chong Chen,?Huanwei Ru,?Li Tan,?Ximin Chi,?Fangjun Wang,?Daming Gao,?Moubin Lin,?Xianming Deng,?Hai Jiang. A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2. Nature Biotechnology. 2025 September 10. doi: 10.1038/s41587-025-02793-8.?
9. Runyang Feng,?Zheyan Fang,?Shuang Zhao,?You-en Zhang,?Na Wu,?Zhenyang Guo,?Xin Zhong,?Bixuan Jiang,?Hongfei Xu,?Hangnan Hong,?Zhentao Zhang,?Mukaddas Abdurahman,?Xueting Yu,?Jilong Geng,?Xiansu Nie,?Supuya Abuduwahapi,?Dong Huang,?Gang Zhao,?Wenbin Zhang,?Hao Lu,?Li Shen,?Xin Zhao,?Zhaoyang Chen,?Junjie Guo,?Hongchao Zheng,?Yue He,?Sanwu Wu,?Jiayin Peng,?Jiawen Song,?Xiao Wang,?Haomin Li,?Yuli Huang,?Shengying Qin,?Haojie Lu,?Xiangdong Wang,?Jianguo Zhao,?Lei Huang*,?Yun Zhao*,?Peng Li*,?Junbo Ge*,?Hua Li*. SIRT6 Lysine-demyristoylates ATF2 to ameliorate vascular injury via PRKCD/VE-Cadherin pathway pegulating vascular endothelial barrier. Advanced Science. 2025 12(41):e04948. doi:10.1002/advs.202504948. (* co-corresponding author)
10. Shanshan Lu,?Yifei Chen,?Jiawen Song,?Liangliang Ren,?Jun Du,?Donglai Shen,?Jiayin Peng,?Yao Yin,?Xia Li,?Yuqing Wang,?Yan Gao,?Siman Han,?Yichang Jia,?Yun Zhao*,?Yizheng Wang*. Cortisol regulates neonatal lung development via Smoothened. Respiratory Research. 2025 Jan 18;26(1):27. ?doi: 10.1186/s12931-025-03104-0 (* co-corresponding author)
11. Fuping Wen,?Yi Han,?Hui Zhang,?Zhangting Zhao,?Wenjia Wang,?Fan Chen,?Weimin Qin,?Junyi Ju,?Liwei An,?Yan Meng,?Jie Yang,?Yang Tang,?Yun Zhao,?Huanhu Zhang,?Feng Li,?Wenqi Bai,?Yuanzhi Xu,?Zhaocai Zhou and?Shi Jiao.?Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression. Nature Communications.?2024 Dec 4;15(1):10543. doi: 10.1038/s41467-024-54850-6.
12. Yang Tang,?Fan Chen,?Gemin Fang,?Hui Zhang,?Yanni Zhang,?Hanying Zhu,?Xinru Zhang,?Yi Han,?Zhifa Cao,?Fenghua Guo,?Wenjia Wang,?Dan Ye,?Junyi Ju,?Lijie Tan,?Chuanchuan Li,?Yun Zhao,?Zhaocai Zhou,?Liwei An,?Shi Jiao.?A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis. EMBO Journal.?2024 Nov;43(22):5586-5612. doi: 10.1038/s44318-024-00257-4.
13. Yitian Shi, Jiayin Peng, Mengfan Liu, Xiling Qi, Siyu Li, Qiangqiang Li, Qing Jiang, Liming Zheng, Jiankun Xu, Yun Zhao* and Yifeng Zhang*. Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation. Theranostics.?2024; 14(15):5999-6015. doi:10.7150/thno.98149. (* co-corresponding author)
14. Zheyan Fang,?Gang Zhao,?Shuang Zhao,?Xueting Yu,?Runyang Feng,?You-En Zhang,?Haomin Li,?Lei Huang,?Zhenyang Guo,?Zhentao Zhang,?Mukaddas Abdurahman,?Hangnan Hong,?Peng Li,?Bing Wu,?Jinhang Zhu,?Xin Zhong,?Dong Huang,?Hao Lu,?Xin Zhao,?Zhaoyang Chen,?Wenbin Zhang,?Junjie Guo,?Hongchao Zheng,?Yue He,?Shengying Qin,?Haojie Lu,?Yun Zhao,?Xiangdong Wang,?Junbo Ge and?Hua Li*. GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases. The Innovation. 2024 Jan 8;5(2):100565. doi: 10.1016/j.xinn.2024.100565
15. Kang Lin,?Yun Zhao,?Yuqi Tang,?Ying Chen,?Moubin Lin and?Luwei He. Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression. Cell Death and Disease. 2024, 15(1): 85. doi:?10.1038/s41419-024-06468-1.
16. Jiayin Peng,?Lili Han,?Biao Liu,?Jiawen Song,?Yuang Wang,?Kunpeng Wang,?Qian Guo,?XinYan Liu,?Yu Li,?Jujin Zhang,?Wenqing Wu,?Sheng Li,?Xin Fu,?Cheng-le Zhuang,?Weikang Zhang,?Shengbao Suo,?Ping Hu*?and Yun Zhao*.?Gli1 marks a sentinel muscle stem cell population for muscle regeneration.?Nature Communications.?2023, 14, 6993. doi: 10.1038/s41467-023-42837-8. (* co-corresponding author)
17. Chaoxiong Wang, Xichen Zheng, Jinlan Zhang, Xiaoyi Jiang, Jia Wang, Yuwei Li, Xiaonan Li, Guanghui Shen, Jiayin Peng, Peixuan Zheng, Yunqing Gu, Jiaojiao Chen, Mobin Lin, Changwen Deng, Hai Gao*, Zhigang Lu*, Yun Zhao*, Min Luo*. CD300ld on neutrophils is required for tumor-driven immune suppression. Nature. 2023, Sep; 621(7980):830-839.?doi: 10.1038/s41586-023-06511-9. (* co-corresponding author)
18. Li Zhang, Lingpu Zhang, Yuqi Wang, Kai Jiang, Chao Gao, Pengfei Zhang, Yujie Xie, Bin Wang, Yun Zhao, Haihua Xiao and Jie Song. Regulating the Surface Topography of CpG Nanoadjuvant via Coordination-Driven Self-assembly for Enhanced Tumor Immunotherapy. Nanoscale Advances. 2023, Jul 26;5(18):4758-4769. doi: 10.1039/d3na00322a.
19. Zhenyang Guo,?Xueting Yu,?Shuang Zhao,?Xin Zhong,?Dong Huang,?Runyang Feng,?Peng Li,?Zheyan Fang,?Yiqing Hu,?Zhentao Zhang,?Mukaddas Abdurahman,?Lei Huang,?Yun Zhao,?Xiangdong Wang,?Junbo Ge and?Hua Li. SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter. Clinical and Translational Medicine. 2023; Aug; 13(8):e1377.?doi: 10.1002/ctm2.1377.
20. Yehua Li, Jiayin Peng*, Yuanxin Xia, Chenyu Pan, Yu Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Qiongni Feng, Wenjia Wang, Shi Jiao, Liwei An, Dianfan Li, Zhaocai Zhou* and Yun Zhao*. Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6. Theranostics.?2023; Jun; 13(11):3761-3780. doi:10.7150/thno.83676. (* co-corresponding author)
21. Guoqing Cai,?Yijun Qi,?Ping Wei,?Hong Gao,?Chenqi Xu,?Yun Zhao,?Xiujuan Qu,?Feng Yao and?Weiwei Yang. IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis. Advanced Science. 2023 Jul;10(21):e2206540. doi: 10.1002/advs.202206540.
22. Wencheng Zhu,?Huiying Chu,?Yajuan Zhang, Tianhang Luo,?Hua Yu,?Hongwen Zhu,?Ye Liu,?Hong Gao,?Yun Zhao,?Quanlin Li, Xiongjun Wang,?Guohui Li?and?Weiwei Yang. Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis. Cell Research. 2023; Mar;33(3):245-257. doi: 10.1038/s41422-022-00773-0.
23. Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou* and Yun Zhao*. Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development. Cell Discovery. 2023; Jan 24;9(1):11. doi: 10.1038/s41421-022-00511-1. (* co-corresponding author)
24. Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou* and Yun Zhao*. Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development. 2022; BioRxiv. doi:10.1101/2022.10.09.511475. (* co-corresponding author)
25. Juan He,?Haoyue Cui,?Xiaohan Shi,?Qiqi Jin,?Ximeng Han,?Tiantian Han,?Jiayin Peng,?Shiwei Guo,?Lei Zhang,?Yun Zhao,?Bin Zhou,?Luonan Chen,?Lei Chen,?Yi Arial Zeng,?Hongyang Wang,?Gang Jin,?Dong Gao. Functional hepatobiliary organoids recapitulate liver development and reveal essential drivers of hepatobiliary cell fate determination. Life Medicine.?2022; Dec 7;1(3):345-358. ?doi: 10.1093/lifemedi/lnac055.
26. Jiayin Peng, Fei Li, Jia Wang, Chaoxiong Wang, Yiao Jiang, Biao Liu, Juan He, Kai Yuan, Chenyu Pan, Moubin Lin, Bin Zhou, Luonan Chen, Dong Gao* and Yun Zhao*. Identification of a rare Gli1⁺ progenitor cell population contributing to liver regeneration during chronic injury. Cell Discovery. 2022; Nov 1; 8(1):118.?doi: 10.1038/s41421-022-00474-3. (* co-corresponding author)
27. Yajuan Zhang,?Ming Zhao,?Hong Gao,?Guanzhen Yu,?Yun Zhao*,?Feng Yao*?and Weiwei Yang*.?MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. Nature Metabolism. 2022; Mar 4; 3:374-388. (* co-corresponding author)
28. Yunqing Gu, Jun Cao, Xinyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Juan He, Jinlan Zhang, Guanghui Shen, Jie Yang, Xichen Zheng, Gaowei Hu, Yuanfei Zhu, Shujuan Du, Yunkai Zhu, Rong Zhang, Jianqing Xu, Fei Lan, Di Qu, Yun Zhao*, Guoliang Xu*, Dong Gao*, Youhua Xie*, Min Luo* and Zhigang Lu*. Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Research. 2022; Jan 32; 1:24-37. doi: 10.1038/s41422-021-00595-6.?(* co-corresponding author)
29. Huihong Jiang,?Erjiang Tang,?Ying Chen,?Hailong Liu,?Yun Zhao*,?Moubin Lin*?and Luwei He*. Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Cancer Science. 2022; Mar 07; 113:971-985?doi: 10.1111/cas.15248.?(* co-corresponding author)
30. Yiao Jiang, Jiayin Peng, Jiawen Song, Juan He, Man Jiang, Jia Wang, Liya Ma, Yuang Wang, Moubin Lin, Hailong Wu, Zhao Zhang, Dong Gao, Yun Zhao*. Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2. Nature Metabolism. 2021; Nov 3; 11:1569-1584. doi: 10.1038/s42255-021-00488-3.?(* co-corresponding author)
31. Yitian Luo,?Guoyue Wan,?Xuan Zhou,?Qiuwen Wang,?Yunbin Zhang,?Juan Bao,?Yao Cong,?Yun Zhao*, Dianfan Li*. Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release. Frontiers in Molecular Biosciences. 2021; Sep 7; 8:701826. doi: 10.3389/fmolb.2021.701826.?eCollection 2021. (* co-corresponding author)
32. Luwei He*, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao*, Moubin Lin*. Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Communications. ?2021; 41(8):726-746. (* co-corresponding author)
33. Hui Zhang,?Moubin Lin,?Chao Dong,?Yang Tang,?Liwei An,?Junyi Ju,?Fuping Wen,?Fan Chen,?Meng Wang,?Wenjia Wang,?Min Chen,?Yun Zhao,?Jixi Li,?Steven X Hou,?Xinhua Lin,?Lulu Hu,?Wenbo Bu,?Dianqing Wu,?Lin Li,?Shi Jiao,?Zhaocai Zhou. An MST4-pβ-Catenin?Thr40?Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Advanced Science. 2021; Sep; 8(17): e2004850. ?doi: 10.1002/advs.202004850.?
34. Yitian Luo,?Guoyue Wan,?Xiang Zhang,?Xuan Zhou,?Qiuwen Wang,?Jialin Fan,?Hongmin Cai,?Liya Ma,?Hailong Wu,?Qianhui Qu*,?Yao Cong*,?Yun Zhao*,?Dianfan Li*. Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure. 2021; 29(11):1286-1294. (* co-corresponding author)
35. Heng Feng?,?Wenhui Xing,?Yujiao Han,?Jun Sun,?Mingxiang Kong?,?Bo Gao,?Yang Yang,?Zi Yin,?Xiao Chen?,?Yun Zhao?,?Qing Bi,?Weiguo Zou. Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 2020; 130(12):6354-6365.
36. Shuo Zhang,?Juan Zhao,?Xiangdong Lv?,?Jialin Fan,?Yi Lu,?Tao Zeng?,?Hailong Wu,?Luonan Chen*?,?Yun Zhao*. Analysis on gene modular network reveals morphogen-directed development robustness in?Drosophila. Cell Discovery. 2020; 6:43. doi: 10.1038/s41421-020-0173-z? (* co-corresponding author)
37. Yang Tang,?Gemin Fang,?Fenghua Guo,?Hui Zhang,?Xiaoxu Chen,?Liwei An,?Min Chen,?Li Zhou,?Wenjia Wang,?Tiantian Ye,?Lei Zhou,?Pingping Nie,?Haijun Yu,?Moubin Lin,?Yun Zhao,?Xinhua Lin,?Zengqiang Yuan,?Shi Jiao,?Zhaocai Zhou. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020; 38(1):115-128.e9. doi: 10.1016/j.ccell.2020.05.019
38. Ke Zhang, Fang Yu,Jian Zhu,Sue Han,Jiehui Chen,Xuanyuan Wu,Yingying Chen,Tingyu Shen,Jiaoyang Liao,Wenke Guo, Xianfa Yang,Ran Wang,Yun Qian, Jiaxin Yang,Leping Cheng,Yun Zhao,Chi-Chung Hui, Jinsong Li,Guangdun Peng,Shuijin He, Naihe Jing,Ke Tang. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neuro developmental Disorders with an?NR2F1?Point Mutation. Cell Reports.?2020; 21;31(3):107521. doi: 10.1016/j.celrep.2020.03.085
39. Liwei An,?Pingping Nie,?Min Chen,?Yang Tang,?Hui Zhang,?Jingmin Guan,?Zhifa Cao,?Chun Hou,?Wenjia Wang,?Yun Zhao,?Huixiong Xu,?Shi Jiao,?Zhaocai Zhou. MST4 Kinase Suppresses Gastric Tumorigenesis by Limiting YAP Activation via a Non-Canonical Pathway. Journal of Experimental Medicine. 2020; 217(6):e20191817.
40. Xue Feng,?Tiantian Lu,?Jinhui Li, Ruizeng Yang,?Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian and Lei Zhang. The tumor suppressor Interferon Regulatory Factor 2 Binding Protein 2 regulates Hippo pathway in liver cancer by a feedback loop in mice. Hepatology.?2020; 71(6):1988-2004
41. Ruoying Yu,?Huihui Wu,?Hazrat Ismail?,?Shihao Du?,?Jun Cao,?Jianyu Wang,?Tarsha Ward,?Fengrui Yang,?Ping Gui,?Mahboob Ali,?Lingluo Chu,?Fei Mo,?Qi Wang,?Youjun Chu,?Yun Zhao,?Mingliang Ye,?Guowei Fang,?Peng R Chen,?Zhen Dou,?Xinjiao Gao,?Wenwen Wang,?Xing Liu,?Xuebiao Yao. Methylation of PLK1 by SET7/9 Ensures Accurate Kinetochore-Microtubule Dynamics. Journal of Molecular Cell Biology. 2020; 12(6):462-476.?
42. Jialin Fan, Yajie Gao, Yi Lu, Wenqing Wu, Shuo Yuan, Hailong Wu, Dahua Chen and Yun Zhao*. PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila. Cell Discovery. 2019; 5:44. (* co-corresponding author)
43. Lingli?He,?Liang?Yuan,?Yang?Sun,?Pingyang?Wang,?Hailin?Zhang,?Xue?Feng,?Zuoyun?Wang,?Wenxiang?Zhang,?Chuanyu Yang,?Yi Arial Zeng, Yun Zhao, Ceshi Chen and Lei Zhang. Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression. Cancer Research.?2019; 79(17):4399-4411
44. Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu, Lei Zhang. Dual function of VGLL4 in muscle regeneration. The EMBO Journal. 2019; 38:e101051
45. Wei Yu,?Xueyan Ma,?Jinjin Xu,?Andreas Wilhelm Heumüller,?Zhaoliang Fei,?Xue Feng,?Xiaodong Wang, Kuo Liu,?Jinhui Li,?Guizhong Cui,?Guangdun Peng,?Hongbin Ji,?Jinsong Li,?Naihe Jing,?Hai Song,?Zhiqiang Lin,?Yun Zhao, Zuoyun Wang,?Bin Zhou,?and?Lei Zhang. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genetics. 2019; 15(2):e1007977.
46. Yang Tang,?Min Chen,?Li Zhou,?Jian Ma,?Yehua Li,?Hui Zhang,?Zhubing Shi,?Qi Xu,?Xiaoman Zhang, Ziyang Gao,?Yun Zhao,?Yunfeng Cheng,?Shi Jiao?and?Zhaocai Zhou. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discovery. 2019; 5:3.
47. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Distinct Functions of Polycomb Group Proteins in Regulating?Ci?Transcription in Developing Drosophila. Journal of Molecular Cell Biology. 2018, 10(5):475-478. (* co-corresponding author)
48. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). Journal of Molecular Cell Biology. 2018, 10(5):437-447. (* co-corresponding author)
49. Wenxiang Zhang,?Jinjin Xu,?Jinhui Li,?Tong Guo,?Dan Jiang,?Xue Feng, Xueyan Ma,?Lingli He,?Wenqing Wu,? Mengxin Yin,?Ling Ge,?Zuoyun Wang, Margaret S. Ho,?Yun Zhao,?Zhaoliang Fei?and?Lei Zhang. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. Journal of Biological Chemistry.?2018, 293(44):17119-17134.
50. Xueyan Ma,?Peixue Li,?Peihao Chen,?Jinhui Li,?Hongling Huang,?Chao Wang, Wenjing Li, Jianping Ding,?Yun Zhao,?Fa-Xing Yu,?Xiangbing Qi?and Lei Zhang. Staurosporine targets the Hippo pathway to inhibit cell growth. Journal of Molecular Cell Biology. 2018, 10(3):267-269.
51. Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Jialin Fan, Hao Chen, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang and Yun Zhao*. UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing. EMBO Reports. 2017, 18(11):1922-1934. (* co-corresponding author)
52. Yuhong Han, Yue Xiong, Xuanming Shi, Jiang Wu, Yun Zhao* and Jin Jiang*. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biology.?2017, 15(8):e2002063. (* co-corresponding author)
53. Shuo Zhang,?Chenyu Pan,?Xiangdong Lv,?Wei Wu,?Hao Chen,?Wenqing Wu,?Hailong Wu,?Lei Zhang,?and?Yun Zhao^*. Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult?Drosophila?testis. Scientific Reports. 2017, 7: 5101. (* co-corresponding author)
54. Xu Xiao, Jing-jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-ping Qiu, Yue Xiong, Lian-fang Yang, Hai-wei Cui, Xiao-long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-liang Li, Wen-wei Qiu and Bao-liang Song. Cholesterol modification of Smoothened is required for Hedgehog signaling. Molecular Cell.?2017, 66(1):154-162.
55. Jiajun Xu,?Xue Hao,?Meng-Xin Yin,?Yi Lu,?Yunyun Jin,?Jinjin Xu,?Ling Ge,?Wenqing Wu, Margaret Ho,?Yingzi Yang,?Yun Zhao and?Lei Zhang. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development.?2017,?144:?1510-1517.
56. Yi Hao,?Qinbo Zhou,?Jing Ma,?Yun Zhao,?and?Shusheng Wang. miR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells. J Clin Exp Ophthalmol. 2016, 7(3): 562.
57. Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang and Yun Zhao^*. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway. eLIFE. 2016, 5:e15690. (* co-corresponding author)
58. Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei^* and Yun Zhao^*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research. 2016, 26:529-542. (* co-corresponding author)
59. Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang, Tong Guo, Hui Han, Haiyun Song, Lei Zhang and Yun Zhao^*. SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adultDrosophilatestis.Development. 2016, 143(10):1655-1662. (* co-corresponding author)
60. Shimin Wang, Yi Lu, Mengxin Yin, Chao Wang, Wei Wu, Jinhui Li, Wenqing Wu, Lianxin Hu, Yun Zhao and Lei Zhang. Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal. Journal of Biological Chemistry. 2016, 291:7926-7937.
61. Chao Wang, Meng-Xin Yin, Wei Wu, Liang Dong, Shimin Wang, Yi Lu, Jinjin Xu, Wenqing Wu, Sheng Li, and Yun Zhao?and Lei Zhang.?Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration.?Cell Discovery.?2016, 2:16006.
62. Lianxin Hu, Jiajun Xu, Meng-Xin Yin, Liguo Zhang, Yi Lu, Wenqing Wu, Zhaoyu Xu, Margaret S. Ho, Guanjun Gao, Yun Zhao?and Lei Zhang.?Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.?Cell Discovery.?2016, 2:15047.
63. Hui Han, Jialin Fan, Yue Xiong, Wenqing Wu, Yi Lu, Lei Zhang and Yun Zhao^*. Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription. Scientific Reports. 2016, 6:18937. (* co-corresponding author)
64. Hui Wang, Zaijun Ma, Kongyan Niu, Yi Xiao, Xiaofen Wu, Chenyu Pan, Yun Zhao, Kai Wang, Yaoyang Zhang and Nan Liu. Antagonistic roles between Nibbler and Hen1 modulate piRNA 3' ends in Drosophila. Development. 2016, 143(3):530-539.
65. Chunying Liu, Yue Xiong, Jing Feng, Lei Zhang and Yun Zhao^*. Sqh?is involved in the regulation of?Ci?stability in Hh signaling pathway. Journal of Molecular Cell Biology. 2015, 7:584-587. (* co-corresponding author)
66. Liang Dong,? Jinhui Li,?Hongling Huang,?Meng-Xin Yin,?Jinjin Xu, Peixue Li,?Yi Lu,?Wenqing Wu,?Hang Yang,?Yun Zhao?and Lei Zhang. Growth suppressor lingerer regulates?bantam microRNA to restrict organ size. Journal of Molecular Cell Biology. 2015, 7(5):415-428.
67. Qian?Hao,?Shi?Jiao,?Zhubing?Shi,?Chuanchuan?Li,?Xia?Meng,?Zhen?Zhang,?Yanyan?Wang, Xiaomin?Song,?Wenjia?Wang,?Rongguang?Zhang,?Yun?Zhao,?Catherine CL?Wong and Zhaocai?Zhou. A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO Journal. 2015, 34(23):2903-2920.
68. Zhao Zhang, Yanyan Wang, Chuanchuan Li, Zhubing Shi, Qian Hao, Wenjia Wang, Xiaomin Song, Yun Zhao, Shi Jiao and Zhaocai Zhou. The transitional endoplasmic reticulum ATPase p97 regulates the alternative nuclear factor NF-κB signaling via partial degradation of the NF-κB subunit p100. Journal of Biological Chemistry. 2015, 290(32):19558-19568.
69. Lin Fu, Xiangdong Lv, Yue Xiaong and Yun Zhao^*. Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET. Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science). 2015, 1322:61-70. (* co-corresponding author)
70. Zizhang Zhou, Xia Yao, Shuang Li, Yue Xiong, Xiaohua Dong, Yun Zhao^#, Jin Jiang^# and Qing Zhang^#. Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling. Developmental Cell. 2015, 34(1):58-72. (#Co-senior author) (* co-corresponding author)
71. Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu, Wenqing Wu, Junhai Han, Zhaocai Zhou, Hai Jiang, Lei Zhang and Yun Zhao^*. Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discovery. 2015, 1:15006. (* co-corresponding author)
72. Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao and Lei Zhang. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications. 2015, 6:6607.
73. Shi Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhubing Shi, Yanyan Wang, Xiaomin Song, Heng Liu, Chunyang Li, Min Chen, Wenjia Wang, Yun Zhao, Zhengfan Jiang, Hongyan Wang, Catherine C L Wong,?Chen Wang and?Zhaocai Zhou. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.?Nature Immunology. 2015, 16(3):246-257.
74. Yue Xiong, Chunying Liu and Yun Zhao^*. Decoding Ci: from partial degradation to inhibition. Development Growth & Differentiation. 2015, 57(2):98-108. (invited review) (* co-corresponding author)
75. Chuanchuan Li, Miao Feng, Zhubing Shi, Qian Hao, Xiaomin Song, Wenjia Wang, Yun Zhao, Shi Jiao and Zhaocai Zhou. Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1. Journal of Biological Chemistry. 2014, 289(52):35969-35978.
76. Lianxin Hu, Hongling Huang, Jinhui Li, Meng-xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control. Journal of Biological Chemistry. 2014, 289(48):33598-33607.?
77. Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang and Yun Zhao^*. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. Journal of Biological Chemistry. 2014, 289(32):22333-22341. (* co-corresponding author)
78. Cuicui Chen, Zhubing Shi, Wenqing Zhang, Min Chen, Feng He, Zhenzhen Zhang, Yicui Wang, Miao Feng, Wenjia Wang, Yun Zhao, Jerry H. Brown, Shi Jiao and Zhaocai Zhou. Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. Journal of Biological Chemistry. 2014, 289(14):9651-9561
79. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin, Ji, Lei Zhang and Zhaocai Zhou. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014, 25(2):166-180.
80. Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Developmental Biology. 2014, 385(2):211-219. (* co-corresponding author)
81. Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-yuan Liu, William Pao, Yun Zhao^*, Haiquan Chen^* and Hongbin Ji^*. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342(1):36-42. (* co-corresponding author)
82. Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou, Feng Liu, Lei Zhang^* and Yun Zhao^*. Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of Ci^R. Journal of Cell Biology. 2013, 203(4):575-583. (* co-corresponding author)
83. Zhao Zhang, Xiangdong Lv, Wen Chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang^* and Yun Zhao^*. Ter94 ATPase complex targets K11-linked ubiquitinated Ci to proteasomes for partial degradation. Developmental Cell. 2013, 25(6):636-644. (* co-corresponding author)
84. Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao^* and Dahua Chen^*. Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover. PLoS Biology. 2013, 11(11):e1001721. (* co-corresponding author)
85. Yan Zhang, Lin Fu, Xiaolong Qi, Zhenyi Zhang, Yuanxin Xia, Jianhang Jia, Jin Jiang, Yun Zhao^* and Geng Wu^*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications. 2013, 4:2608. (* co-corresponding author)
86. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S Ho, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. eLIFE. 2013, 2:e00999. (* co-corresponding author)
87. Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang^* and Yun Zhao^*. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of Cell Science. 2013, 126(18):4230-4238. (* co-corresponding author)
88. Tong Guo, Yi Lu, Peixue Li, Mengxin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao^* and Lei Zhang^*. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research. 2013, 23(10):1201-1214.? (* co-corresponding author)
89. Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao^*, Xin-Yuan Liu^* and Lei Zhang^*. Par-1 regulates tissue growth by influencing Hippo phosphorylation status and Hippo-Salvador association. PLoS Biology. 2013, 11(8):e1001620. (* co-corresponding author)
90. Zhao Zhang, Chenyu Pan and Yun Zhao^*. Hedgehog in the Drosophila testis niche: what does it do there? Protein and Cell. 2013, 4(9):650-655. (invited review) (* co-corresponding author)
91. Xiangdong Lv, Lin Fu and Yun Zhao^*. aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC. Acta Biochimica et Biophysica Sinica. 2013, 45(7):610-611. (invited review) ?(* co-corresponding author)
92. Min Luo,?Te Ling,?Wenbing Xie,?He Sun,?Yonggang Zhou,?Qiaoyun Zhu,?Meili Shen,?Le Zong,?Guoliang Lyu,?Yun Zhao, Tao Ye,?Jun Gu,?Wei Tao,?Zhigang Lu and Ingrid Grummt. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells. 2013, 31(7):1278-1286.?
93. Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang^* and Yun Zhao^*. Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.?Journal of Biological Chemistry. 2013,?288:12605-12614. (* co-corresponding author)
94. Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang^* and Yun Zhao^*. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis.?Cell Research. 2013, 23:573-576. (* co-corresponding author)
95. Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao^* and Zhaocai Zhou^*. Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.?Structure. 2013, 21:449-461. (* co-corresponding author)
96. Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guogang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang and Zhaocai Zhou. Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure. 2013, 21:680-688.
97. Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I Greene and Zhaocai Zhou. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Research. 2012, 22:1440-1452.
98. Shuo Shi, Yue-Zhen Deng, Jiang-Sha Zhao, Xiao-Dan Ji, Jun Shi, Yu-Xiong Feng, Guo Li, Jing-Jing Li, Di Zhu, H. Phillip Koeffler, Yun Zhao and Dong Xie. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. Journal of Biological Chemistry. 2012, 287(11):7845-7858.
99. Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao^* and Lei Zhang^*. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control.?Journal of Biological Chemistry.?2012, 287:5784-5796. (* co-corresponding author)
100. Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang^* and Yun Zhao^*. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.?Cell Research. 2011, 21:1436-1451. (* co-corresponding author)