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2009年畢業(yè)于美國康涅狄格大學(xué)醫(yī)學(xué)院獲生物醫(yī)學(xué)博士學(xué)位，同時獲商學(xué)院工商管理學(xué)碩士學(xué)位。同年5月作為獨立PI獲得Connecticut Stem Cell Seed Award研究經(jīng)費資助，受聘于康涅狄格大學(xué)干細胞學(xué)院從事博士后研究，并于2010年5月任助理教授。2011年1月回國任中國科學(xué)院生物化學(xué)與細胞生物學(xué)研究所研究員，從事核糖核酸生物學(xué)研究。迄今，發(fā)表學(xué)術(shù)論文百余篇，其中通訊作者論文90余篇，包括發(fā)表在Cell、Nature、Science期刊12篇（含4篇綜述/展望）及其子刊20余篇。Google Scholar引用超3.7萬次。獲選首批新基石研究員、HHMI國際研究員、國際RNA學(xué)會科研中期成就獎、FAOBMB卓越研究獎、中國青年科技獎特別獎、科學(xué)探索獎、談家楨生命科學(xué)創(chuàng)新獎等學(xué)術(shù)獎勵?！碍h(huán)形RNA生成和功能機制的研究”獲國家自然科學(xué)獎二等獎（第一完成人）。目前擔(dān)任核糖核酸功能與應(yīng)用全國重點實驗室主任、中國生物物理學(xué)會副理事長、中國生物化學(xué)與分子生物學(xué)會基因?qū)I(yè)分會主任。自2020年起，同時擔(dān)任Science、Cell、Molecular Cell等期刊的科學(xué)顧問或編委。

　　近年來的研究表明長非編碼RNAs和環(huán)形RNAs廣泛參與一系列細胞的重要功能調(diào)控，包括細胞核亞結(jié)構(gòu)的形成、基因表達的遺傳與表觀遺傳調(diào)控等。我們實驗室主要研究哺乳動物細胞中這些具有調(diào)控功能的RNAs，包括新類型分子發(fā)現(xiàn)、其加工成熟機制、其在轉(zhuǎn)錄、染色體、細胞核亞結(jié)構(gòu)和干細胞干性維持等方面的功能、以及相關(guān)應(yīng)用潛能。主要研究內(nèi)容如下：

　　1、通過轉(zhuǎn)錄組測序和計算生物學(xué)手段結(jié)合的方法，發(fā)掘和鑒定人類基因組中的新類型RNA分子

　　2、利用分子生物學(xué)、細胞生物學(xué)和生物化學(xué)的手段，研究RNA分子在基因表達調(diào)控中的作用機制及應(yīng)用

　　3、采用基因組編輯和活細胞成像等手段，研究RNA在細胞核亞結(jié)構(gòu)和染色體維持和調(diào)控過程中的功能

　　4、以干細胞多能性維持和分化為模型，研究RNA對干細胞的命運決定的調(diào)控

　　研究成果將能夠豐富我們對長非編碼RNAs和環(huán)形RNAs功能和機制的認識，拓展不同類型RNA的應(yīng)用潛能，并為全面認識細胞命運可塑性提供一個全新水平的調(diào)控。

　　我們實驗室在充分尊重和鼓勵個人興趣愛好的前提下，致力于為學(xué)生和博士后提供全面的指導(dǎo)，培養(yǎng)科學(xué)探索精神和職業(yè)道德，共同營造一個具有歸屬感、成就感的環(huán)境，使我們做出最好、最有創(chuàng)新性的工作。在此我們真誠歡迎對科學(xué)研究抱有熱情和理想的你來報考博士生、碩士生，并真誠歡迎博士后加入。

1. Pan YH^#, Shan L^#, Zhang YY^#, Yang ZH, Zhang Y, Cao SM, Liu XQ, Zhang J, Yang L and Chen LL*. 2025. Pre-rRNA spatial distribution and functional organization of the nucleolus. Nature, 646(8083):227-235.
2. Liu XQ^#, Li Pan^#, Gao BQ^#, Zhu HL, Yang LZ, Wang Y, Zhang YY, Wu H, Pan YH, Shan L, Yu HT, Yang L and Chen LL*. 2025. De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses. Cell, 188(17):4586-4603.
3. Feng X^#, Jiang BW^#, Zhai SN, Liu CX, Wu H, Zu BQ, Wei MY, Wei J, Yang L and Chen LL*. 2025. Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models. Nat Biotechnol, AOP Mar 31^th.
4. Tao X^#, Zhai SN^#, Liu CX^#, Huang YK, Wei J, Guo YL, Liu XQ, Li X, Yang L* and Chen LL*. 2025. Degradation of circular RNA by the ribonuclease DIS3. Mol Cell, 85(8):1674-1685.
5. Guo SK^#, Liu CX^#, Xu YF^#, Wang X^#, Nan F^#, Huang YK, Li SQ, Nan S, Li L, Kon E, Li C, Wei MY, Su R, Wei J, Peng SG, Ad-El N, Liu JQ, Peer D, Chen T, Yang L and Chen LL*. 2025. Therapeutic application of circular RNA aptamers in a mouse model of psoriasis. Nat Biotechnol, 43(2):236-246.
6. Chen LL* and Kim VN*. 2024. Small and long non-coding RNAs: past, present, and future. Cell, 187(23):6451-6485.
7. Chen LL*. 2024. Linking a neurodevelopmental disorder with a lncRNA deletion. New Engl J Med, 391(16):1542-1545.
8. Liu CX, Yang L and Chen LL*. 2024. Dynamic conformation: marching toward circular RNA function and application. Mol Cell, 84(19):3596-3609.
9. Shan L and Chen LL*. 2024. Unveiling the mystery of nuclear RNA homeostasis. Cell Stem Cell, 31(5):583-585.
10. Cao SM^#, Wu H^#, Yuan GH^#, Pan YH, Zhang J, Liu YX, Li SQ, Xu YF, Wei MY, Yang L and Chen LL*. 2024. Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function. Mol Cell, 84(12):2304-2319.
11. Yang LZ^#, Min YH^#, Liu YX^#, Gao BQ, Liu XQ, Huang YK, Wang HF, Yang L, Liu Z and Chen LL*. 2024. CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells. Nat Methods, 21(9):1646-1657.
12. Shan L^#, Li P^#, Yu HT* and Chen LL*. 2023. Emerging roles of nuclear bodies in genome spatial organization. Trends Cell Biol, 34(7):595-605.
13. Shan L^#, Xu G^#, Yao RW, Luan PF, Huang YK, Zhang PH, Pan YH, Zhang L, Gao X, Li Y, Cao SM, Gao SX, Yang ZH, Li SQ, Yang LZ, Wang Y, Wong CCL, Yu L, Li JS, Yang L and Chen LL*. 2023. Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature, 615(7952):526-534.
14. Chen LL*, Bindereif A, Bozzoni I, Chang HY, Matera GA, Gorospe M, Hansen TB, Kjems J, Ma XK, Pek JW, Rajewsky N, Salzman J, Wilusz JE*, Yang L* and Zhao F. 2023. A guide to naming eukaryotic circular RNAs. Nat Cell Biol, 25(1):1-5.
15. Chen LL*. 2022. Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function. Nat Methods, 19(10):1152-1155.
16. Liu CX and Chen LL*. 2022. Circular RNAs: characterization, cellular roles, and applications. Cell, 185(12):2016-2034.
17. Yang L^*, Wilusz JE^* and Chen LL*. 2022. Biogenesis and regulatory roles of circular RNAs. Annu Rev Cell Dev Biol, 38:263-289.
18. Liu CX^#, Guo SK^#, Nan F, Xu YF, Yang L and Chen LL*. 2022. RNA circles with minimized immunogenicity as potent PKR inhibitors. Mol Cell, 82(2):420-434.
19. Liu CX and Chen LL*. 2021. Expanded regulation of circular RNA translation. Mol Cell, 81(20):4111-4113.
20. Wu M^#, Xu G^#, Han C^#, Luan PF, Xing YH, Nan F, Yang LZ, Huang YK, Yang ZH, Shan L, Yang L, Liu JQ* and Chen LL*. 2021. lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription. Science, 373(6554):547-555.
21. Statello L^#, Guo CJ^#, Chen LL* and Huarte M*. 2021. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol, 22(2):96-118.
22. Li SQ^#, Li X^#, Xue W^#, Zhang L^#, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li J^*, Yang L^* and Chen LL*. 2021. Screening for functional circular RNAs using the CRISPR-Cas13 system. Nat Methods, 18(1):51-59.
23. Guo CJ, Xu G and Chen LL*. 2020. Mechanisms of long noncoding RNA nuclear retention. Trends Biochem Sci, 45(11):947-960.
24. Chen LL*. 2020. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol, 21(8):475-490.
25. Guo CJ^#, Ma XK^#, Xing YH, Zheng CC, Xu YF, Shan L, Zhang J, Wang SH, Wang YM, Carmichael GG, Yang L and Chen LL*. 2020. Distinct processing of lncRNAs contributes to non-conserved functions in stem cells. Cell, 181(3):621-636.
26. Yang LZ^#, Wang Y^#, Li SQ, Yao RW, Luan PF, Wu H, Carmichael GG and Chen LL*. 2019. Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems. Mol Cell, 76(6):981-997.
27. Yao RW^#, Xu G^#, Wang Y, Shan L, Luan PF, Wang Y, Wu M, Yang LZ, Xing YH, Yang L and Chen LL*. 2019. Nascent pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus. Mol Cell, 76(5):767-783.
28. Liu CX^#, Li X^#, Nan F^#, Jiang S, Gao X, Guo SK, Xue W, Cui YG, Dong KG, Ding HH, Qu B, Zhou ZC, Shen N^*, Yang L^* and Chen LL*. 2019. Structure and degradation of circular RNAs regulate PKR activation in innate immunity. Cell, 177(4):865-880.
29. Yao RW^#, Wang Y^# and Chen LL*. 2019. Cellular functions of long noncoding RNAs. Nat Cell Biol, 21(5):542-551.
30. Wang Y^#, Hu SB^#, Wang MR^#, Yao RW, Wu D, Yang L and Chen LL*. 2018. Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria. Nat Cell Biol, 20(10):1145-1158.
31. Li X, Yang L* and Chen LL*. 2018. The biogenesis, functions, and challenges of circular RNAs. Mol Cell, 71(3):428-442.
32. Xiang JF^#, Yang Q^#, Liu CX^#, Wu M, Chen LL* and Yang L*. 2018. N⁶-methyladenosines modulate A-to-I RNA editing. Mol Cell, 69(1):126-135.
33. Li X^#, Liu CX^#, Xue W^#, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L* and Chen LL*. 2017. Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection. Mol Cell, 67(2):214-227.
34. Xing YH^#, Yao RW^#, Zhang Y^#, Guo CJ, Jiang S, Xu G, Dong R, Yang L and Chen LL*. 2017. SLERT regulates DDX21 rings associated with Pol I transcription. Cell, 169(4):664-678.
35. Yang L* and Chen LL*. 2017. Enhancing the RNA engineering toolkit. Science, 358(6366):996-997. ?
36. Wu H, Yang L* and Chen LL*. 2017. The diversity of long noncoding RNAs and their generation. Trends Genet, 33(8):540-552.
37. Chen LL* and Yang L*. 2017. AlUternative regulation for gene expression. Trends Cell Biol, 27(7):480-490.
38. Wu H^#, Yin QF^#, Luo Z^#, Yao RW, Zheng CC, Zhang J, Xiang JF, Yang L and Chen LL*. 2016. Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins. Mol Cell, 64(3):534-548.
39. Chen LL*. 2016. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol, 17(4):205-211.
40. Chen LL*. 2016. Linking long noncoding RNA localization and function. Trends Biochem Sci, 41(9):761-772.
41. Chen LL* and Yang L*. 2015. Gear up in circles. Mol Cell, 58(5):715-717.
42. Zhang XO^#, Wang HB^#, Zhang Y, Lu XH, Chen LL* and Yang L*. 2014. Complementary sequence-mediated exon circularization. Cell, 159(1):134-147.
43. Yang L* and Chen LL*. 2014. Microexons go big. Cell, 159(7):1488-1489.
44. Zhang Y^#, Zhang XO^#, Chen T, Xiang JF, Yin QF, Xing YH, Zhu SS, Yang L* and Chen LL*. 2013. Circular intronic long noncoding RNAs. Mol Cell, 51(6):792-806.
45. Yin QF^#, Yang L^#, Zhang Y, Xiang JF, Wu YW, Carmichael GG* and Chen LL*. 2012. Long noncoding RNAs with snoRNA ends. Mol Cell, 48(2):219-230.
46. Yang L, Duff MO, Graveley BR, Carmichael GG and Chen LL*. 2011. Genomewide characterization of non-polyadenylated RNAs. Genome Biol, 12(2):R16.

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