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　　1995年畢業(yè)于武漢大學(xué)，獲學(xué)士學(xué)位;2001年畢業(yè)于中科院上海生化所，獲博士學(xué)位。2001年11月至2012年1月于美國德州大學(xué)西南醫(yī)學(xué)中心從事博士后研究。2012年2月起，在中科院上海生物化學(xué)與細(xì)胞生物學(xué)研究所任研究員，研究組長。

　　當(dāng)病原體入侵高等有機(jī)體時(shí)，會(huì)引發(fā)免疫反應(yīng)，包括天然免疫和適應(yīng)性免疫。天然免疫反應(yīng)起始于宿主細(xì)胞的受體分子對病原體上的特異分子或者其它“異己”成分的識別，隨后激活特定的信號通路，誘導(dǎo)相應(yīng)基因表達(dá),防御病原體侵染。譬如當(dāng)病毒感染細(xì)胞時(shí)，病毒相關(guān)的核酸分子會(huì)被細(xì)胞內(nèi)的受體分子識別而激活相應(yīng)的信號通路，誘導(dǎo)抗病毒的干擾素產(chǎn)生。天然免疫反應(yīng)能夠?yàn)橛袡C(jī)體提供及時(shí)的保護(hù)，但是其信號異常也可能導(dǎo)致自身免疫疾病等后果。腫瘤發(fā)生過程中產(chǎn)生的危險(xiǎn)信號分子也可以激活天然免疫反應(yīng)，誘導(dǎo)炎癥。我們近期聚焦RIG-I-MAVS信號通路，利用生物化學(xué)和分子生物學(xué)方法在細(xì)胞和動(dòng)物水平上來解析其中的分子細(xì)胞機(jī)制，研究該信號通路與自身免疫疾病發(fā)生的相關(guān)性及其在腫瘤治療中的功能作用。

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