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　　許琛琦，研究員，1998年于華東師范大學獲得生物化學專業(yè)學士，2004年于中科院生化細胞所獲得生物化學與分子生物學博士學位，2004-2009年于哈佛大學Dana-Farber腫瘤研究所從事博士后研究，獲得Arthritis Foundation資助，后晉升為Instructor。2009年底加入中科院生化與細胞所，入選國家基金杰出青年基金。闡明了抗原免疫應答調(diào)控的新機制并發(fā)展了腫瘤免疫治療的新策略。工作已發(fā)表于Cell 2020, Nature 2018，Nature 2016，Nature 2013等，兩項成果入選中國科學十大進展/中國生命科學十大進展，其發(fā)明專利已成功進入轉(zhuǎn)化。榮獲上海市青年科技杰出貢獻獎(2020年)，中國青年科技獎(2018年)，中國生化與分子生物學會Promega生物化學獎(2018年)等榮譽。

• 　　圖3. 基于膽固醇代謝調(diào)控的腫瘤免疫治療新方法。膽固醇酯化酶ACAT1可以將細胞內(nèi)的游離膽固醇轉(zhuǎn)化為膽固醇酯。抑制CD8+ T細胞的ACAT1活性可以使細胞質(zhì)膜的游離膽固醇水平上升，從而使得TCR信號增強并讓殺傷性免疫突觸更成熟。T細胞腫瘤抗原免疫應答由此變得更加高效。

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