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我們以組織生理病理類器官模型、小鼠模型和臨床腫瘤標本的整合分析為基礎，運用類器官培養(yǎng)技術、單細胞多組學測序技術、空間多組學測序技術、細胞譜系示蹤技術等分子細胞生物學技術手段，整合生物信息學分析方法，研究成體干細胞和腫瘤細胞命運可塑性的分子調(diào)控網(wǎng)絡和治療抵抗機理，篩選抗腫瘤新靶點，開發(fā)新型抗癌藥物，合作開展相關臨床試驗，延長腫瘤患者的生存。目前的主要研究內(nèi)容包括：

1)研究成體干細胞和腫瘤祖細胞，尋找維持成體干細胞多能性的主要調(diào)控基因，并基于此建立并優(yōu)化類器官培養(yǎng)技術體系；

2)體外重建不同時期的腫瘤類器官模型，研究腫瘤細胞可塑性與腫瘤抗藥性的分子機理；

3)建立來源于中國癌癥病人的類器官模型庫，進行高通量藥物篩選，探尋新的抗腫瘤藥物靶點，發(fā)展新型抗癌藥物，合作開展相關臨床試驗。

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