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人才隊(duì)伍

陳玲玲
研究員，研究組長，博士生導(dǎo)師
E-mail: linglingchen@@sibcb.ac.cn
實(shí)驗(yàn)室主頁: http://chenlab-rna.sibcb.ac.cn

個(gè)人簡介：

2009年畢業(yè)于美國康涅狄格大學(xué)醫(yī)學(xué)院獲生物醫(yī)學(xué)博士學(xué)位，同時(shí)獲商學(xué)院工商管理學(xué)碩士學(xué)位。同年5月作為獨(dú)立PI獲得Connecticut Stem Cell Seed Award研究經(jīng)費(fèi)資助，受聘于康涅狄格大學(xué)干細(xì)胞學(xué)院從事博士后研究，并于2010年5月任助理教授。2011年1月回國任中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所研究員，從事核糖核酸生物學(xué)研究。迄今，發(fā)表學(xué)術(shù)論文百余篇，其中通訊作者論文90余篇，包括發(fā)表在Cell、Nature、Science期刊12篇（含4篇綜述/展望）及其子刊20余篇。Google Scholar引用超3.7萬次。獲選首批新基石研究員、HHMI國際研究員、國際RNA學(xué)會科研中期成就獎(jiǎng)、FAOBMB卓越研究獎(jiǎng)、中國青年科技獎(jiǎng)特別獎(jiǎng)、科學(xué)探索獎(jiǎng)、談家楨生命科學(xué)創(chuàng)新獎(jiǎng)等學(xué)術(shù)獎(jiǎng)勵(lì)?！碍h(huán)形RNA生成和功能機(jī)制的研究”獲國家自然科學(xué)獎(jiǎng)二等獎(jiǎng)（第一完成人）。目前擔(dān)任核糖核酸功能與應(yīng)用全國重點(diǎn)實(shí)驗(yàn)室主任、中國生物物理學(xué)會副理事長、中國生物化學(xué)與分子生物學(xué)會基因?qū)I(yè)分會主任。自2020年起，同時(shí)擔(dān)任Science、Cell、Molecular Cell等期刊的科學(xué)顧問或編委。

社會任職：

研究方向：

RNA加工代謝與功能機(jī)制

研究工作：

　　人類基因組測序計(jì)劃發(fā)現(xiàn)多于98%的轉(zhuǎn)錄基因組序列為非編碼RNA(ncRNA)。這些ncRNA包括人們所熟知的housekeepingncRNA(如tRNAs, rRNAs和snRNAs等)、小RNA(如miRNAs和piRNAs等)，以及上萬條長非編碼RNA(lncRNA，>200nt)。最近幾年來的研究表明lncRNAs廣泛參與一系列細(xì)胞的重要功能調(diào)控，包括細(xì)胞核亞結(jié)構(gòu)的形成、基因表達(dá)的遺傳與表觀遺傳調(diào)控等。
　　我們實(shí)驗(yàn)室主要研究哺乳動物細(xì)胞中l(wèi)ncRNAs的功能調(diào)控，包括新類型lncRNA分子的發(fā)掘、其加工成熟機(jī)制、以及它們在轉(zhuǎn)錄、染色體、細(xì)胞核亞結(jié)構(gòu)和干細(xì)胞干性維持等方面的調(diào)控功能研究。未來五年，我們主要研究以下內(nèi)容：
　　1、通過轉(zhuǎn)錄組測序和計(jì)算生物學(xué)手段結(jié)合的方法，發(fā)掘和鑒定人類基因組中的新類型lncRNA分子
　　2、利用分子生物學(xué)、細(xì)胞生物學(xué)和生物化學(xué)的手段，研究新lncRNA分子在基因表達(dá)調(diào)控中的作用機(jī)制
　　3、采用基因組編輯和活細(xì)胞成像等技術(shù)手段，研究lncRNA在細(xì)胞核亞結(jié)構(gòu)和染色體維持和調(diào)控過程中的功能
　　4、以hESCs的多功能潛能性維持和分化為模型，研究lncRNA對人源胚胎干細(xì)胞的命運(yùn)決定的調(diào)控
　　研究成果將能夠豐富我們對lncRNAs功能和機(jī)制的認(rèn)識，也為hESCs的多功能性維持和命運(yùn)改變提供一個(gè)全新水平的調(diào)控。

承擔(dān)科研項(xiàng)目情況：

代表論著：

1. Pan YH^#, Shan L^#, Zhang YY^#, Yang ZH, Zhang Y, Cao SM, Liu XQ, Zhang J, Yang L and Chen LL*. 2025. Pre-rRNA spatial distribution and functional organization of the nucleolus. Nature, 646(8083):227-235.
2. Liu XQ^#, Li Pan^#, Gao BQ^#, Zhu HL, Yang LZ, Wang Y, Zhang YY, Wu H, Pan YH, Shan L, Yu HT, Yang L and Chen LL*. 2025. De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses. Cell, 188(17):4586-4603.
3. Feng X^#, Jiang BW^#, Zhai SN, Liu CX, Wu H, Zu BQ, Wei MY, Wei J, Yang L and Chen LL*. 2025. Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models. Nat Biotechnol, AOP Mar 31^th.
4. Tao X^#, Zhai SN^#, Liu CX^#, Huang YK, Wei J, Guo YL, Liu XQ, Li X, Yang L* and Chen LL*. 2025. Degradation of circular RNA by the ribonuclease DIS3. Mol Cell, 85(8):1674-1685.
5. Guo SK^#, Liu CX^#, Xu YF^#, Wang X^#, Nan F^#, Huang YK, Li SQ, Nan S, Li L, Kon E, Li C, Wei MY, Su R, Wei J, Peng SG, Ad-El N, Liu JQ, Peer D, Chen T, Yang L and Chen LL*. 2025. Therapeutic application of circular RNA aptamers in a mouse model of psoriasis. Nat Biotechnol, 43(2):236-246.
6. Chen LL* and Kim VN*. 2024. Small and long non-coding RNAs: past, present, and future. Cell, 187(23):6451-6485.
7. Chen LL*. 2024. Linking a neurodevelopmental disorder with a lncRNA deletion. New Engl J Med, 391(16):1542-1545.
8. Liu CX, Yang L and Chen LL*. 2024. Dynamic conformation: marching toward circular RNA function and application. Mol Cell, 84(19):3596-3609.
9. Shan L and Chen LL*. 2024. Unveiling the mystery of nuclear RNA homeostasis. Cell Stem Cell, 31(5):583-585.
10. Cao SM^#, Wu H^#, Yuan GH^#, Pan YH, Zhang J, Liu YX, Li SQ, Xu YF, Wei MY, Yang L and Chen LL*. 2024. Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function. Mol Cell, 84(12):2304-2319.
11. Yang LZ^#, Min YH^#, Liu YX^#, Gao BQ, Liu XQ, Huang YK, Wang HF, Yang L, Liu Z and Chen LL*. 2024. CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells. Nat Methods, 21(9):1646-1657.
12. Shan L^#, Li P^#, Yu HT* and Chen LL*. 2023. Emerging roles of nuclear bodies in genome spatial organization. Trends Cell Biol, 34(7):595-605.
13. Shan L^#, Xu G^#, Yao RW, Luan PF, Huang YK, Zhang PH, Pan YH, Zhang L, Gao X, Li Y, Cao SM, Gao SX, Yang ZH, Li SQ, Yang LZ, Wang Y, Wong CCL, Yu L, Li JS, Yang L and Chen LL*. 2023. Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Nature, 615(7952):526-534.
14. Chen LL*, Bindereif A, Bozzoni I, Chang HY, Matera GA, Gorospe M, Hansen TB, Kjems J, Ma XK, Pek JW, Rajewsky N, Salzman J, Wilusz JE*, Yang L* and Zhao F. 2023. A guide to naming eukaryotic circular RNAs. Nat Cell Biol, 25(1):1-5.
15. Chen LL*. 2022. Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function. Nat Methods, 19(10):1152-1155.
16. Liu CX and Chen LL*. 2022. Circular RNAs: characterization, cellular roles, and applications. Cell, 185(12):2016-2034.
17. Yang L^*, Wilusz JE^* and Chen LL*. 2022. Biogenesis and regulatory roles of circular RNAs. Annu Rev Cell Dev Biol, 38:263-289.
18. Liu CX^#, Guo SK^#, Nan F, Xu YF, Yang L and Chen LL*. 2022. RNA circles with minimized immunogenicity as potent PKR inhibitors. Mol Cell, 82(2):420-434.
19. Liu CX and Chen LL*. 2021. Expanded regulation of circular RNA translation. Mol Cell, 81(20):4111-4113.
20. Wu M^#, Xu G^#, Han C^#, Luan PF, Xing YH, Nan F, Yang LZ, Huang YK, Yang ZH, Shan L, Yang L, Liu JQ* and Chen LL*. 2021. lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription. Science, 373(6554):547-555.
21. Statello L^#, Guo CJ^#, Chen LL* and Huarte M*. 2021. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol, 22(2):96-118.
22. Li SQ^#, Li X^#, Xue W^#, Zhang L^#, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li J^*, Yang L^* and Chen LL*. 2021. Screening for functional circular RNAs using the CRISPR-Cas13 system. Nat Methods, 18(1):51-59.
23. Guo CJ, Xu G and Chen LL*. 2020. Mechanisms of long noncoding RNA nuclear retention. Trends Biochem Sci, 45(11):947-960.
24. Chen LL*. 2020. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol, 21(8):475-490.
25. Guo CJ^#, Ma XK^#, Xing YH, Zheng CC, Xu YF, Shan L, Zhang J, Wang SH, Wang YM, Carmichael GG, Yang L and Chen LL*. 2020. Distinct processing of lncRNAs contributes to non-conserved functions in stem cells. Cell, 181(3):621-636.
26. Yang LZ^#, Wang Y^#, Li SQ, Yao RW, Luan PF, Wu H, Carmichael GG and Chen LL*. 2019. Dynamic imaging of RNA in living cells by CRISPR-Cas13 systems. Mol Cell, 76(6):981-997.
27. Yao RW^#, Xu G^#, Wang Y, Shan L, Luan PF, Wang Y, Wu M, Yang LZ, Xing YH, Yang L and Chen LL*. 2019. Nascent pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus. Mol Cell, 76(5):767-783.
28. Liu CX^#, Li X^#, Nan F^#, Jiang S, Gao X, Guo SK, Xue W, Cui YG, Dong KG, Ding HH, Qu B, Zhou ZC, Shen N^*, Yang L^*and Chen LL*. 2019. Structure and degradation of circular RNAs regulate PKR activation in innate immunity. Cell, 177(4):865-880.
29. Yao RW^#, Wang Y^# and Chen LL*. 2019. Cellular functions of long noncoding RNAs. Nat Cell Biol, 21(5):542-551.
30. Wang Y^#, Hu SB^#, Wang MR^#, Yao RW, Wu D, Yang L and Chen LL*. 2018. Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria. Nat Cell Biol, 20(10):1145-1158.
31. Li X, Yang L* and Chen LL*. 2018. The biogenesis, functions, and challenges of circular RNAs. Mol Cell, 71(3):428-442.
32. Xiang JF^#, Yang Q^#, Liu CX^#, Wu M, Chen LL* and Yang L*. 2018. N⁶-methyladenosines modulate A-to-I RNA editing. Mol Cell, 69(1):126-135.
33. Li X^#, Liu CX^#, Xue W^#, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L* and Chen LL*. 2017. Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection. Mol Cell, 67(2):214-227.
34. Xing YH^#, Yao RW^#, Zhang Y^#, Guo CJ, Jiang S, Xu G, Dong R, Yang L and Chen LL*. 2017. SLERT regulates DDX21 rings associated with Pol I transcription. Cell, 169(4):664-678.
35. Yang L* and Chen LL*. 2017. Enhancing the RNA engineering toolkit. Science, 358(6366):996-997. ?
36. Wu H, Yang L* and Chen LL*. 2017. The diversity of long noncoding RNAs and their generation. Trends Genet, 33(8):540-552.
37. Chen LL* and Yang L*. 2017. AlUternative regulation for gene expression. Trends Cell Biol, 27(7):480-490.
38. Wu H^#, Yin QF^#, Luo Z^#, Yao RW, Zheng CC, Zhang J, Xiang JF, Yang L and Chen LL*. 2016. Unusual processing generates SPA lncRNAs that sequester multiple RNA binding proteins. Mol Cell, 64(3):534-548.
39. Chen LL*. 2016. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol, 17(4):205-211.
40. Chen LL*. 2016. Linking long noncoding RNA localization and function. Trends Biochem Sci, 41(9):761-772.
41. Chen LL* and Yang L*. 2015. Gear up in circles. Mol Cell, 58(5):715-717.
42. Zhang XO^#, Wang HB^#, Zhang Y, Lu XH, Chen LL* and Yang L*. 2014. Complementary sequence-mediated exon circularization. Cell, 159(1):134-147.
43. Yang L* and Chen LL*. 2014. Microexons go big. Cell, 159(7):1488-1489.
44. Zhang Y^#, Zhang XO^#, Chen T, Xiang JF, Yin QF, Xing YH, Zhu SS, Yang L* and Chen LL*. 2013. Circular intronic long noncoding RNAs. Mol Cell, 51(6):792-806.
45. Yin QF^#, Yang L^#, Zhang Y, Xiang JF, Wu YW, Carmichael GG* and Chen LL*. 2012. Long noncoding RNAs with snoRNA ends. Mol Cell, 48(2):219-230.
46. Yang L, Duff MO, Graveley BR, Carmichael GG and Chen LL*. 2011. Genomewide characterization of non-polyadenylated RNAs. Genome Biol, 12(2):R16.

獲獎(jiǎng)及榮譽(yù)：

研究組成員：

合影

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個(gè)人簡介：

社會任職：

研究方向：

研究工作：

承擔(dān)科研項(xiàng)目情況：

代表論著：

獲獎(jiǎng)及榮譽(yù)：

研究組成員：